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排序方式: 共有77条查询结果,搜索用时 15 毫秒
41.
Photodynamic therapy (PDT) is a potentially immunogenic and FDA‐approved antitumor treatment modality that utilizes the spatiotemporal combination of a photosensitizer, light and oftentimes oxygen, to generate therapeutic cytotoxic molecules. Certain photosensitizers under specific conditions, including ones in clinical practice, have been shown to elicit an immune response following photoillumination. When localized within tumor tissue, photogenerated cytotoxic molecules can lead to immunogenic cell death (ICD) of tumor cells, which release damage‐associated molecular patterns and tumor‐specific antigens. Subsequently, the T‐lymphocyte (T cell)–mediated adaptive immune system can become activated. Activated T cells then disseminate into systemic circulation and can eliminate primary and metastatic tumors. In this review, we will detail the multistage cascade of events following PDT of solid tumors that ultimately lead to the activation of an antitumor immune response. More specifically, we connect the fundamentals of photochemically induced ICD with a proposition on potential mechanisms for PDT enhancement of the adaptive antitumor response. We postulate a hypothesis that during the course of the immune stimulation process, PDT also enriches the T‐cell repertoire with tumor‐reactive activated T cells, diversifying their tumor‐specific targets and eliciting a more expansive and rigorous antitumor response. The implications of such a process are likely to impact the outcomes of rational combinations with immune checkpoint blockade, warranting investigations into T‐cell diversity as a previously understudied and potentially transformative paradigm in antitumor photodynamic immunotherapy. 相似文献
42.
Sherif A. Abdel-Gawad Obaid Afzal Hany H. Arab Alhumaidi B. Alabbas Abdulmalik M. Alqarni 《Molecules (Basel, Switzerland)》2021,26(16)
Accurate and precise application of ion-selective electrodes (ISEs) in the quantification of environmental pollutants is a strenuous task. In this work, the electrochemical response of alendronate sodium trihydrate (ALN) was evaluated by the fabrication of two sensitive and delicate membrane electrodes, viz. polyvinyl chloride (PVC) and glassy carbon (GC) electrodes. A linear response was obtained at concentrations from 1 × 10−5 to 1 × 10−2 M for both electrodes. A Nernstian slope of 29 mV/decade over a pH range of 8–11 for the PVC and GC membrane electrodes was obtained. All assay settings were carefully adjusted to obtain the best electrochemical response. The proposed technique was effectively applied for the quantification of ALN in pure form and wastewater samples, acquired from manufacturing industries. The proposed electrodes were effectively used for the determination of ALN in real wastewater samples without any prior treatment. The current findings guarantee the applicability of the fabricated ISEs for the environmental monitoring of ALN. 相似文献
43.
Rana Shafia Nawaz M. Alharbi Sayer Obaid 《Journal of Thermal Analysis and Calorimetry》2021,143(1):421-429
Journal of Thermal Analysis and Calorimetry - Theoretical investigation about the role of hybrid nanoparticles to enhance the effective thermal conductivity of working micropolar fluid over a... 相似文献
44.
Computational Management Science - The two objectives of max min fairness (MMF) in multi commodity networks are maximizing the overall throughput so the network operator is satisfied when network... 相似文献
45.
We propose a mathematical theorem to prove the positive definiteness of the term FI used in Finite Element Tearing and Interconnecting introduced by Farhat [1]. Furthermore, we introduce a new idea to extend FETI to include non-self adjoint operators emerging from, for example, elastoplastic large deformation, non-associative plasticity or when coupling BEM and FEM [2]. (© 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
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Ijaz Hussain Abdullah Aitani Zuhair Malaibari Hassan Alasiri Muhammad Naseem Akhtar Obaid Fahad Aldosari Shakeel Ahmed 《Chemical record (New York, N.Y.)》2023,23(4):e202200294
Chemical upcycling of waste plastics into high-value-added products is one of the most effective, cost-efficient, and environmentally beneficial solutions. Many studies have been published over the past few years on the topic of recycling plastics into usable materials through a process called catalytic pyrolysis. There is a significant research gap that must be bridged in order to use catalytic pyrolysis of waste plastics to produce high-value products. This review focuses on the enhanced catalytic pyrolysis of waste plastics to produce jet fuel, diesel oil, lubricants, aromatic compounds, syngas, and other gases. Moreover, the reaction mechanism, a brief and critical comparison of different catalytic pyrolysis studies, as well as the techno-feasibility analysis of waste plastic pyrolysis and the proposed catalytic plastic pyrolysis setup for commercialization is also covered. 相似文献
49.
Houston D. Cole Menitte Eroy John A. Roque III Ge Shi Mina Guirguis John Fakhry Colin G. Cameron Girgis Obaid Sherri A. McFarland 《Photochemistry and photobiology》2023,99(2):751-760
Osmium (Os) based photosensitizers (PSs) are a unique class of nontetrapyrrolic metal-containing PSs that absorb red light. We recently reported a highly potent Os(II) PS, rac-[Os(phen)2(IP-4T)](Cl)2, referred to as ML18J03 herein, with light EC50 values as low as 20 pm . ML18J03 also exhibits low dark toxicity and submicromolar light EC50 values in hypoxia in some cell lines. However, owing to its longer oligothiophene chain, ML18J03 is not completely water soluble and forms 1–2 μm sized aggregates in PBS containing 1% DMSO. This aggregation causes variability in PDT efficacy between assays and thus unreliable and irreproducible reports of in vitro activity. To that end, we utilized PEG-modified DPPC liposomes (138 nm diameter) and DSPE-mPEG2000 micelles (10.2 nm diameter) as lipid nanoformulation vehicles to mitigate aggregation of ML18J03 and found that the spectroscopic properties important to biological activity were maintained or improved. Importantly, the lipid formulations decreased the interassay variance between the EC50 values by almost 20-fold, with respect to the unformulated ML18J03 when using broadband visible light excitation (P = 0.0276). Herein, lipid formulations are presented as reliable platforms for more accurate in vitro photocytotoxicity quantification for PSs prone to aggregation (such as ML18J03) and will be useful for assessing their in vivo PDT effects. 相似文献
50.
Mudhi AlAli Maream Alqubaisy Mariam Nasser Aljaafari Asma Obaid AlAli Laila Baqais Aidin Molouki Aisha Abushelaibi Kok-Song Lai Swee-Hua Erin Lim 《Molecules (Basel, Switzerland)》2021,26(9)
Nutraceuticals are essential food constituents that provide nutritional benefits as well as medicinal effects. The benefits of these foods are due to the presence of active compounds such as carotenoids, collagen hydrolysate, and dietary fibers. Nutraceuticals have been found to positively affect cardiovascular and immune system health and have a role in infection and cancer prevention. Nutraceuticals can be categorized into different classes based on their nature and mode of action. In this review, different classifications of nutraceuticals and their potential therapeutic activity, such as anti-cancer, antioxidant, anti-inflammatory and anti-lipid activity in disease will be reviewed. Moreover, the different mechanisms of action of these products, applications, and safety upon consumers including current trends and future prospect of nutraceuticals will be included. 相似文献